Use of apoptosis-specific eif-5a sirna to down regulate...

Details Use of apoptosis-specific eif-5a sirna to down regulate... Use of apoptosis-specific eif-5a sirna to down regulate...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01)

Patent

CA 2634814

The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5-A1, nucleic acids and polypeptides and methods for down regulating pro- inflammatory cytokines in a mammal by administering siRNA against eIF-5A1 to the mammal to treat/prevent sepsis and/or hemorrhagic shock.

La présente invention concerne le facteur 5A eucaryotique d'initiation spécifique de l'apoptose (eIF-5A), dénommé eIF-5A ou eIF5-A1 spécifique de l'apoptose, des acides nucléiques et des polypeptides, ainsi que des méthodes de régulation négative de cytokines pro-inflammatoires chez un mammalien qui consistent à administrer à celui-ci de l'ARNsi contre eIF5-A1 afin de traiter/prévenir une septicémie et/ou un choc hémorragique.

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