A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/47 (2006.01) C07D 215/12 (2006.01) C07D 215/227 (2006.01) C07D 221/06 (2006.01) C07D 221/10 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2338298
Novel tricyclic compounds having structural formula (I) as disclosed herein having the natural steroidal trans-anti-trans relative configuration at the A, B, C ring structure are inhibitors of 5-alpha reductase. The inventive compounds are useful in the treatment of hyperandrogenic conditions. They are also useful in the treatment of sweat-related conditions and in the treatment and prevention of premature labor.
La présente invention concerne des composés tricycliques inhibiteurs de la 5-.alpha. réductase. Ces composés qui sont structurellement représentés par la formule (I) présentent la configuration relative trans-anti-trans stéroïdienne naturelle au niveau de la structure de cycles A, B, C. Les composés de l'invention conviennent au traitement des états hyperandrogéniques. Ces composés conviennent également au traitement des états concernés par la sécrétion sudorale et à la prévention du travail prématuré.
Aster Susan D.
Graham Donald W.
von Langen Derek
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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