Gene therapy of hiv-positive patients by the expression of...

Details Gene therapy of hiv-positive patients by the expression of... Gene therapy of hiv-positive patients by the expression of...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 14/16 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2392468

The invention relates to the genetically engineered treatment of an HIV infection by the expression of membrane-anchored gp41 peptides. With this treatment vectors are made available for the first time which code for a fusion protein that contains a peptide derived from gp41 of HIV and a carboxy terminal by means of a trans-membrane anchor tagged to a flexible linker.

L'invention concerne le traitement génétique d'une infection par le HIV par l'expression de peptides gp41 à ancrage par membrane. A cet effet, des vecteurs sont pour la première fois mis à disposition, qui codent pour une protéine de fusion contenant un peptide dérivé du gp41 du HIV et un ancrage trans-membrane C-terminal attaché par un lieur flexible.

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