A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/165 (2006.01) A61K 31/16 (2006.01) A61P 25/22 (2006.01)
Patent
CA 2672494
Compounds of Formula I are useful for the treatment of anxiety disorders such as generalized anxiety disorder (GAD), panic attack, post traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD) and social phobias. wherein: A is chosen from: aryl or heteroaryl, A being optionally substituted with up to 5 independently-selected groups R8; R1 is chosen from: alkyl or haloalkyl; R2 is chosen from: H, C(O)R6, C(O)OR6, SO2R6 or C(O)NR6R7; R3, R4 and R5 are independently chosen from: H or alkyl; R6and R7 are independently chosen from: H or alkyl; and R8 is chosen from: OH, CN, halo, alkyl, alkoxy, haloalkyl, haloalkoxy, C(O)R6, C(O)OR6, SO2R6 or C(O)NR6R7.
Les composés représentés par la Formule I sont utiles pour le traitement de troubles de l'anxiété, tels que le trouble de l'anxiété généralisée (TAG), l'attaque de panique, le trouble de stress post-traumatique (SPT), le trouble obsessionnel compulsif(TOC) et les phobies sociales. Formule dans laquelle : A est choisi parmi : aryle ou hétéroaryle, A étant facultativement substitué par jusqu'à 5 groupes R8 choisis de façon indépendante ; R1 est choisi parmi : alkyle ou haloalkyle ; R2 est choisi parmi : H, C(O)R6, C(O)OR6, SO2R6 ou C(O)NR6R7 ; R3, R4 et R5 sont indépendamment choisis parmi : H ou alkyle ; R6 et R7 sont indépendamment choisis parmi : H ou alkyle ; et R8 est choisi parmi : OH, CN, halo, alkyle, alcoxy, haloalkyle, haloalcoxy, C(O)R6, C(O)OR6, SO2R6 ou C(O)NR6R7.
Higgins Guy
Isaac Methvin
Slassi Abdelmalik
Blake Cassels & Graydon Llp
Nps Pharmaceuticals Inc.
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