Osteoblast-specific mitogens and drugs containing such...

C - Chemistry – Metallurgy – 07 – F

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C07F 9/09 (2006.01) A61K 31/66 (2006.01) C07F 9/113 (2006.01)

Patent

CA 2304821

The invention is directed to compounds of formula (I) wherein R1 - alkyl, alkenyl or alkynyl having from 6 to 24 carbon atoms; n = 0 - 12; X = oxygen or NH; and the physiologically safe salts, esters, optically active forms, racemates and derivatives thereof which can be metabolized in vivo to yield compounds of general formula (I), methods of preparing same, and drugs containing said compounds, for treating bone metabolic disorders.

L'invention a trait à des composés répondant à la formule (I) dans laquelle R<1> représente un alkyle, un alcényle ou un alcynyle comportant de 6 à 24 atomes de carbone, où la valeur de n est comprise entre 0 et 12 et où X représente un oxygène ou NH. Cette invention porte également sur des sels, des esters, des formes actives du point de vue optique, des composés racémiques et des dérivés de ceux-ci, ne présentant pas de risques du point de vue physiologique, pouvant être métabolisés in vivo afin de donner des composés correspondant à la formule générale (I). Elle concerne de surcroît des méthodes de préparation de ces composés et des médicaments les renfermant et ce, aux fins du traitement de troubles du métabolisme osseux.

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