C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 1/04 (2006.01) C07G 99/00 (2009.01) A61K 31/00 (2006.01) C12N 1/20 (2006.01)
Patent
CA 2336135
The present invention relates to a compound named Mumbaistatin which is obtainable by cultivation of the microorganism HIL-008003 (DSM 11641), and to its pharmaceutically acceptable salts and derivatives. Mumbaistatin is a glucose-6-phosphate translocase inhibitor and can be used in the treatment of diabetes mellitus. The present invention further relates to a process for the production of Mumbaistatin, to the microorganism HIL-008003 (DSM 11641), to the use of Mumbaistatin and its pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use in the treatment of diabetes mellitus, and to pharmaceutical compositions comprising Mumbaistatin or a pharmaceutically acceptable salt or derivative thereof.
L'invention concerne un composé dénommé Mumbaïstatine, que l'on peut obtenir à partir d'une culture du micro-organisme HIL-008003 (DSM 11641), ainsi que les sels et dérivés de celui-ci, pharmaco-acceptables. La Mumbaïstatine constitue un inhibiteur de la glucose-6-phosphate translocase et on peut l'utiliser dans le traitement du diabète sucré. L'invention concerne en outre un procédé de production de la Mumbaïstatine, le micro-organisme HIL-008003 (DSM 11641), l'utilisation de la Mumbaïstatine et des sels et dérivés de celle-ci pharmaco-acceptables, en tant que médicaments, notamment leur utilisation dans le traitement du diabète sucré, ainsi que des compositions pharmaceutiques contenant la Mumbaïstatine ou un sel ou dérivé pharmaco-acceptable de celle-ci.
Deshmukh Sunil Kumar
Kogler Herbert
Kota Sridevi
Kumar Erra Koteswara Satya Vijaya
Kurz Michael
Aventis Pharma Deutschland Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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