Peptide, production and use thereof

Details Peptide, production and use thereof Peptide, production and use thereof

C - Chemistry, Metallurgy

07

K

C07K 7/02 (2006.01) A61K 38/04 (2006.01) C07K 5/02 (2006.01) C07K 14/575 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2086079

PEPTIDE PRODUCTION AND USE THEREOF ABSTRACT OF THE DISCLOSURE A peptide represented by the formula: Image [I] wherein R1 represents an oil-soluble group; R2 and R5 represent a hydrogen atom or a lower alkyl group; R3- represents an aliphatic group which may have O or S; R4 represents a heterocyclic-substituted lower alkyl group; R6 represents a hydrogen atom, a lower alkyl group or an aromatic cyclic group; X represents a group having an aromatic ring; n represents an integer of 0 or more and m represents an integer of 2 or more, or a salt thereof exhibits a marked endothelin receptor-antagonistic action, and the peptide [I] is pharmaceutically useful as a therapeutic agent for hypertension, cardiovascular disease and renal disease, for instance.

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