A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/495 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01)
Patent
CA 2128699
2128699 9314758 PCTABS00024 3-Arylindole or 3-arylindazole derivatives having general formula (I) wherein Ar is optionally substituted phenyl or a hetero aromatic group; R1-R4 are hydrogen, halogen, alkyl, alkoxy, hydroxy, alkylthio, alkylsulfonyl, alkyl- or dialkylamino, cyano, trifluoromethyl, or trifluoromethylthio; X is N, CR6, R6 being H, halogen, trifluoromethyl or alkyl, or CH2; Y is N, CH or C; R5 is H, alkyl, alkenyl, cycloalkyl, or cycloalkylalkyl, or R5 is a substituent of formula (1a) or (1b), wherein n is 2 - 6; W is O or S; U is N or CH; Z is -(CH2)m-, -CH=CH-, phenylene, -COCH2-, or -CSCH2-; V is O, S, CH2 or NR7 wherein R7 is H, alkyl, alkenyl, cycloalkyl or cycloalkylalkyl; U1 is O, S, CH2 or NR8; and V1 is NR9R10, OR11, SR12 or CR13R14R15, where each of R8-R15 are as defined for R7; inhibit the firing of spontaneously active dopamine neurones in the ventral tegmental area of the brain and are thus useful for the treatment of psychoses in humans.
Andersen Kim
Skarsfeldt Torben
H. Lundbeck A/s
Robic
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