Recombinant and mutant adenoviruses derived of bovine...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/861 (2006.01) A61K 48/00 (2006.01) C12N 7/01 (2006.01)

Patent

CA 2365911

The present invention provides viral vectors. In one embodiment, the present invention provides mutant and recombinant bovine adenoviruses having a deletion and/or insertion of DNA in the early gene region 4 (E4). In another embodiment, the present invention provides mutant and recombinant bovine adenovirus 1 viruses having a deletion and/or insertion of DNA in the early gene region 3 (E3). The present invention also contemplates the use of the viral vectors for vaccination, gene therapy or other applications as suitable.

L'invention concerne des vecteurs viraux. Selon un mode de réalisation, cette invention concerne des adénovirus bovins recombinants et mutants ayant une délétion et/ou une insertion d'ADN dans la région 4 de gène précoce (E4). Selon un autre mode de réalisation, cette invention a trait à des virus d'adénovirus 1 bovins mutants et recombinants, possédant une délétion et/ou une insertion d'ADN dans la région 3 de gène précoce (E3). La présente invention porte également sur l'utilisation de vecteurs viraux dans le cadre de vaccination, de thérapie génique et d'autres applications dérivées.

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