Storage-stable and bio-stable formulations of ace...

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/55 (2006.01) A61K 9/20 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01)

Patent

CA 2515745

The present invention provides storage-stable and bio-stable formulations of ACE inhibitors, especially enalapril maleate and quinapril hydrochloride, that can be manufactured in a time efficient and cost effective manner. Such formulations can be prepared simply and on a large industrial scale using conventional methods and equipment. The present invention also provides methods for the preparation of highly manufacturable, storage-stable and bio- stable formulations of ACE inhibitors, especially enalapril maleate and quinapril hydrochloride. Methods for treatment of cardiovascular disorders using storage-stable and bio-stable formulations of ACE inhibitors, especially enalapril maleate and quinapril hydrochloride, are also provided.

La présente invention concerne des formulations stables au stockage et biologiquement stables d'inhibiteurs des ACE (Angiotensin Converting Enzymes), et plus particulièrement l'énalapril sous forme de maléate et le quinapril sous forme d'hydrochlorure, qui se prêtent à une fabrication économe en temps et en coûts. Ces formulations admettent une production simple et à échelle industrielle par des moyens et selon des procédés conventionnels. L'invention concerne également des procédés pour l'élaboration d'inhibiteurs des ACE, stables au stockage et biologiquement stables, et plus particulièrement de l'énalapril sous forme de maléate et du quinapril sous forme d'hydrochlorure. L'invention concerne enfin des procédés convenant au traitement de troubles cardio-vasculaires au moyen de formulations stables au stockage et biologiquement stables d'inhibiteurs des ACE, et plus particulièrement, de l'énalapril sous forme de maléate et du quinapril sous forme d'hydrochlorure.

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