A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/14 (2006.01) A61K 9/50 (2006.01) A61K 47/48 (2006.01)
Patent
CA 2509429
The present invention relates to liquid sustained release suspension dosage forms comprising ionized forms of water-soluble drugs. In particular, the invention encompasses a liquid form controlled release drug composition comprising a dispersed phase comprising an ion-exchange matrix drug complex comprising a pharmaceutically acceptable ion-exchange matrix and a water- soluble electrolytic drug associated with the ion-exchange matrix, wherein the surface charge of the ion-exchange matrix is opposite that of the electrolytic drug and a dispersion medium substantially free of diffusible counterions, further comprising a polyelectrolyte having the same charge as the electrolytic drug. The invention also provides methods for preparing such compositions and methods of treatment.
Cette invention concerne des formes pharmaceutiques liquide en suspension, à libération soutenue, comprenant des formes ionisées de médicaments hydrosolubles. L'invention concerne en particulier une composition médicamenteuse liquide à libération contrôlée contenant une phase dispersée constituée elle-même d'un complexe médicamenteux à matrice d'échange ionique qui renferme une matrice d'échange ionique pharmaceutiquement acceptable et un médicament électrolytique hydrosoluble associé à ladite matrice - la charge superficielle de cette matrice étant opposée à celle du médicament électrolytique et d'un milieu de dispersion sensiblement exempt de contre-ions diffusibles - ainsi qu'une polyélectrolyte de même charge que le médicament électrolytique. L'invention concerne également des procédés de préparation de telles compositions et des méthodes de traitement.
Hollenbeck Garry R.
Jiang Xiaojian
Osler Hoskin & Harcourt Llp
University Of Maryland Baltimore
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