C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 251/86 (2006.01) A61K 31/15 (2006.01) A61K 31/27 (2006.01) C07D 281/04 (2006.01)
Patent
CA 2647045
Provided are various compounds of Formula (I): Also provided are pharmaceutical compositions comprising the above compounds. Additionally, methods of inhibiting macrophage migration inhibitory factor (MIF) activity in a mammal are provided, as are methods of treating or preventing inflammation in a mammal. Further provided are methods of treating a mammal having sepsis, septicemia, and/or endotoxic shock. Also provided are methods of treating a mammal having an autoimmune disease, and methods of treating a mammal having a tumor.
La présente invention concerne divers composés de formule (I) : . L'invention concerne de plus des compositions pharmaceutiques comprenant les composés ci-dessus, des procédés permettant d'inhiber l'activité du facteur d'inhibition de la migration des macrophages (MIF) chez un mammifère, ainsi que des procédés de traitement ou de prévention de l'inflammation chez un mammifère. L'invention concerne en outre des procédés de traitement d'un mammifère présentant une sepsie, une septicémie, et/ou un choc endotoxique. L'invention concerne enfin des procédés de traitement d'un mammifère atteint d'une maladie auto-immune, et des procédés de traitement d'un mammifère présentant une tumeur.
Osler Hoskin & Harcourt Llp
The Feinstein Institute For Medical Research
LandOfFree
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