Pyridinyl-quinolone compounds, their preparation and use

Details Pyridinyl-quinolone compounds, their preparation and use Pyridinyl-quinolone compounds, their preparation and use

C - Chemistry, Metallurgy

07

D

167/226, 260/277

C07D 401/10 (2006.01) A61K 31/47 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2025150

PYRIDINYL-QUINOLONE COMPOUNDS, THEIR PREPARATION AND USE ABSTRACT Fluorinated 1-cyclopropyl-7-(substituted-pyri- dinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids of the formula Image wherein R id hydrogen, R' and R" are hydrogen or fluoro, and Z is 3- or 4-pyridinyl substituted by alkyl groups or substituted alkyl groups, are superior antibacterial agents. They are prepared via a coupling reaction between the corresponding esters (R = alkyl) having a halo group in the 7-position and a substituted (trialkylstannyl)- pyridine.

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