A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/485 (2006.01) A61K 9/16 (2006.01) A61K 9/26 (2006.01) A61K 9/52 (2006.01) C07D 489/02 (2006.01)
Patent
CA 2144500
A controlled release pharmaceutical preparation, particularly for oral administration, comprises diamorphine, or a pharmaceutically acceptable salt thereof, as active ingredients, preferably in admixture with a hydrophobic fusible carrier or diluent. The controlled release preparation can be produced without the use of water in a granulation step, or other process features leading to degradation of the diamorphine. The products therefore demonstrate long-term stability in storage and dissolution rates are stable over a long period of time. Such preparation is useful for reducing severe pain and has the additional advantages of only needing to be administered twice or one-a-day.
Brown Miller Ronald
Knott Trevor John
Leslie Stewart Thomas
Mohammad Hassan
Prater Derek Allan
Borden Ladner Gervais Llp
Euro-Celtique S.a.
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