C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/415 (2006.01) A61K 31/505 (2006.01) A61K 45/06 (2006.01) A61P 9/00 (2006.01) C07D 221/00 (2006.01) C07D 231/00 (2006.01)
Patent
CA 2429312
The invention relates to novel pyrazolopyridine derivatives of the formula (I), wherein R1 represents 4-pyridinyl or 3-pyridinyl; R2 represents H, NH2 or halogen, and to the salts, isomers and hydrates thereof as stimulators of the soluble guanylate cyclase and for the use as agents for treating cardiovascular diseases, hypertonia, thromboembolic diseases and ischemias, sexual dysfunction or inflammations and for treating diseases of the central nervous system.
L'invention concerne de nouveaux dérivés de pyrazolopyridine de formule (I) dans laquelle R?1¿ représente 4-pyridinyle ou 3-pyridinyle ; R?2¿ représente H, NH¿2? ou halogène. L'invention concerne également des sels, isomères et hydrates de ces nouveaux dérivés. L'invention concerne en outre leur utilisation comme stimulants de la guanylate cyclase soluble et comme agent pour traiter des maladies cardiovasculaires, l'hypertonie, les maladies trombo-emboliques et les ischémies, les dysfonctionnements sexuels ou les infections, ainsi que pour traiter des maladies du système nerveux central.
Alonso-Alija Cristina
Dembowsky Klaus
Feurer Achim
Flubacher Dietmar
Lang Dieter
Aktiengesellschaft Bayer
Bayer Schering Pharma Aktiengesellschaft
Fetherstonhaugh & Co.
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