C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 3/06 (2006.01) A61K 31/70 (2006.01) A61K 31/7028 (2006.01) A61P 9/00 (2006.01) A61P 21/00 (2006.01) A61P 35/00 (2006.01) C07H 15/08 (2006.01) C07H 15/18 (2006.01)
Patent
CA 2350759
This invention provides smooth muscle cell proliferation inhibitors of formula (I) having the structure wherein X is (A) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10, are each, independently, hydrogen, acyl of 2-7 carbon atoms, perfluoroacyl of 2-10 carbon atoms, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, benzoyl, benzyl or -SO3M; M is hydrogen, lithium, sodium, potassium or ammonium; R11 is hydrogen, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atomes, halogen, nitrile, nitro, or alkoxy of 1-6 carbon atoms; R12 is hydrogen, nitro, amino, acylamino of 2-7 carbon atoms, perfluoroacylamino of 2-7 carbon atoms, alkylamino of 1-6 carbon atoms, perfluoroalkylamino of 1-6 carbon atoms, dialklylamino where each alkyl chain is independently 1-6 carbon atoms, perfluorodialklylamino where each alkyl chain is independently 1-6 carbon atoms, alkylsulfonylamino of 1-6 carbon atoms, perfluoroalkyl-sulfonylamino of 1-6 carbon atoms, arylsulfonylamino of 6-10 carbon atoms or arylsulfonylamino substituted with halo of 6-10 carbon atoms; or a pharmaceutically acceptable salt thereof.
La présente invention concerne des inhibiteurs de la prolifération des cellules des muscles lisses représentés par la formule générale (I), ou certains de leurs sels pharmaceutiquement admis. Dans cette formule générale (I), X est tel que représenté par la formule (A). R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, R?9¿ et R?10¿ sont chacun indépendamment C¿2?-C¿7? acyle, C¿2?-C¿10? perfluoroacyle, C¿1?-C¿6? alkyle, C¿1?-C¿6? perfluoroalkyle, benzoyle, benzyle ou -SO¿3?M; M est hydrogène, lithium, sodium, potassium ou ammonium; R?11¿ est hydrogène, C¿1?-C¿6? alkyle; R?12¿ est hydrogène, nitro, amino, C¿2?-C¿7? acylamino, C¿2?-C¿7? perfluoroacylamino, C¿1?-C¿6? alkylamino, C¿1?-C¿6? perfluoroalkylamino, dialklylamino où chaque chaîne alkyle est indépendamment C¿1?-C¿6? alkyle, perfluorodialklylamino où chaque chaîne alkyle est indépendamment C¿1?-C¿6? alkyle, C¿1?-C¿6? alkylsulfonylamino, C¿1?-C¿6? perfluoroalkylsulfonylamino, C¿1?-C¿6? arylsulfonylamino ou arylsulfonylamino substitué par C¿6?-C¿10? halo.
American Home Products Corporation
Ridout & Maybee Llp
LandOfFree
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