Mutant reoviruses and methods of making and using

Details Mutant reoviruses and methods of making and using Mutant reoviruses and methods of making and using

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) A61K 35/76 (2006.01) A61P 35/00 (2006.01) C07K 14/14 (2006.01) C12N 15/46 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2680661

The present invention provides for a mutant reovirus and a genetically-engineered ISVP. Specifically, the present invention provides a mutant reovirus that lacks or exhibits a reduced expression of the sigma3 polypeptide or that lacks a functional sigma3 polypeptide. The mutant reovirus described therein can be used to generate and stably propagate ISVP. Compositions including the mutant reovirus and methods of using such mutant reovirus are also provided.

La présente invention porte sur un réovirus mutant et un ISVP synthétisé par génie génétique. De manière spécifique, la présente invention concerne un réovirus mutant qui n'a pas ou présente une expression réduite du polypeptide sigma3 ou qui n'a pas de polypeptide sigma3 fonctionnel. Le réovirus mutant décrit ici peut être utilisé pour générer et pour propager de façon stable l'ISVP. L'invention porte également sur des compositions comprenant le réovirus mutant et sur des procédés d'utilisation d'un tel réovirus mutant.

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