Osteoclastogenesis inhibitors and uses thereof

Details Osteoclastogenesis inhibitors and uses thereof Osteoclastogenesis inhibitors and uses thereof

A - Human Necessities

61

K

A61K 31/57 (2006.01) A61K 31/121 (2006.01) A61K 31/216 (2006.01)

Patent

CA 2536380

The present invention provides a method of reducing or inhibiting osteoclast development induced by the receptor for activation of nuclear factor kappa B ligand (RANKL), comprising the step of contacting said osteoclast, or a precursor of the osteoclast, with a pharmacologically effective dose of compounds such as diferuloylmethane, guggulsterone, 1'-Acetoxychavicol or analogues thereof.

La présente invention concerne un procédé permettant de réduire ou inhiber le développement d'ostéoclastes induit par le ligand du récepteur activateur du facteur kappa B nucléaire (RANKL). Le procédé décrit dans cette invention comprend l'étape qui consiste à mettre en contact l'ostéoclaste, ou un précurseur de celui-ci, avec une dose pharmaceutiquement efficace de composés, tels que diféruloylméthane, guggulstérone, 1'-acétoxychavicol ou des analogues de ceux-ci.

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