C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01)
Patent
CA 2676216
The present invention provides aripiprazole obtained by a process for preparing aripiprazole in a high purity and a high yield. According to the process of the present invention, aripiprazole is prepared by the reaction of a carbostyril compound represented by general formula (2): (see formula 2) (wherein X is halogen atom, lower alkanesulfonyloxy group, arylsulfonyloxy group or an aralkylsulfonyloxy group), with a piperazine compound represented by formula (3): (see formula 3) and/or a salt thereof in water, in the presence of 0.5 to 10 mol of an inorganic basic compound, per mol of the carbostyril compound (2).
Tsujimori Hisayuki
Yamaguchi Tatsuya
Fetherstonhaugh & Co.
Otsuka Pharmaceutical Co. Ltd.
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