Substituted pyrazolopyrimidines and thiazolopyrimidines used...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 487/04 (2006.01) A61K 31/505 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) C07D 231/00 (2006.01) C07D 239/00 (2006.01) C07D 277/00 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2440760

The invention relates to substituted pyrazolopyrimidines and thiazolopyrimidines with the general structures (I A), (see formula I A) and (I B) (see formula I B) to a method for their production, to substance libraries containing the same, to medicaments containing said compounds, to the use of said compounds in the production of medicaments for treating pain, epilepsy, schizophrenia, neurodegenerative diseases, in particular Alzheimer's disease, Huntington's disease and Parkinson's disease, for treating cerebral ischaemia and infarcts, psychosis caused by increased amino acid levels, cerebral oedema, conditions caused by an under-supply of the central nervous system, in particular in hypoxia, especially newborn hypoxia and anoxia, for treating AIDS-related dementia, encephalomyelitis, Tourette's syndrome, perinatal asphyxia, tinnitus, neuropathic pain, diseases of the respiratory tract, cancer, cardiac arrythmia, immune disorders and diseases, inflammatory conditions and diseases, renal shutdown, dyssomnia, strokes, thromboses, urinary incontinence, diabetes, psoriasis, septicaemic shock, cerebral traumas, glaucoma and/or congestive heart failure. The invention further relates to pharmaceutical compositions containing said compounds.

La présente invention concerne des pyrazolopyrimidines et thiazolopyrimidines de la structure générale (I A), (I B) et (II), leurs procédés de production, des bibliothèques de substances les contenant, des médicaments contenant ces composés, l'utilisation de ces composés pour la production de médicaments destinés au traitement de douleurs, d'épilepsie, de schizophrénie, de maladies neurodégénératives, notamment la maladie d'Alzheimer, la maladie de Huntington et la maladie de Parkinson, d'ischémies cérébrales et d'infarctus, de psychoses dues à une augmentation des niveaux d'acides aminés, d'oedèmes cérébraux, à des états dus à une sous-alimentation du système nerveux central, notamment en cas d'hypoxie, notamment de l'hypoxie du nouveau né, et d'anoxies, de la démence du sida, d'encéphalomyélite, du syndrome de Tourette, d'asphyxie périnatale, en cas d'acouphène, de douleurs neurophathiques, de maladies des voies respiratoires, de cancers, d'arythmies cardiaques, de troubles et de maladies du système immunitaire, d'états et de maladies inflammatoires, de maladies neurodégénératives, de la maladie de Parkinson, d'insuffisance rénale, de schizophrénie, de troubles du sommeil, d'attaque d'apoplexie, de thromboses, d'incontinence d'urine, de diabètes, de psoriasis, de choc septique, de traumatisme cérébral, de glaucome et/ou d'insuffisance congestive. L'invention concerne également les compositions pharmaceutiques contenant ces composés.

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