Modified protein kinase a-specific oligonucleotides and...

Details Modified protein kinase a-specific oligonucleotides and... Modified protein kinase a-specific oligonucleotides and...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/70 (2006.01) C07H 21/04 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2283626

Disclosed are synthetic, modified oligonucleotides complementary to, and capable of down-regulating the expression of, nucleic acid encoding protein kinase A subunit RI.alpha.. The modified oligonucleotides have from about 15 to about 30 nucleotides and are hybrid, inverted hybrid, or inverted chimeric oligonucleotides. Also disclosed are therapeutic compositions containing such oligonucleotides and methods of using the same.

L'invention concerne des oligonucléotides modifiés synthétiques, qui complètent l'acide nucléique codant la sous-unité RI¿.alpha.? de la protéine kinase A, et peuvent rétro-réguler l'expression dudit acide nucléique. Lesdits oligonucléotides modifiés contiennent entre environ 15 et 30 nucléotides et sont des oligonucléotides hybrides, hybrides inversés ou chimériques inversés. L'invention concerne en outre des compositions thérapeutiques contenant lesdits oligonucléotides et des méthodes d'utilisation associées.

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