Modified glp-1 receptor agonists and their pharmacological...

Details Modified glp-1 receptor agonists and their pharmacological... Modified glp-1 receptor agonists and their pharmacological...

A - Human Necessities

61

K

A61K 38/00 (2006.01) C07K 14/605 (2006.01)

Patent

CA 2497794

This invention relates to modified GLP-1 receptor agonists comprising a GLP-1 receptor agonist linked to a polyethylene glycol polymer having a molecule weight of greater than 30 kD, and related formulations and dosages and methods of administration thereof for therapeutic purposes are provided. More particularly, these modified GLP-1 receptor agonists, compositions and methods are useful in providing a treatment option for those individuals afflicted with a metabolic disorder such as diabetes and prediabetic states such as impaired glucose tolerance, and impaired fasting glucose, by inducing glucose- dependent insulin secretion, without reducing gastrointestinal motility.

L'invention concerne des agonistes modifiés du récepteur GLP-1 comprenant un agoniste du récepteur GLP-1 lié à un polymère de polyéthylèneglycol de poids moléculaire supérieur à 30 kD, ainsi que des formulations associées, des doses et des procédés d'administration de ces agonistes dans des buts thérapeutiques. Ces agonistes modifiés du récepteur GLP-1, compositions et procédés sont plus particulièrement utiles en ce qu'ils constituent une option de traitement pour ceux qui sont affectés d'un trouble métabolique tel que diabète et état prédiabétique, comme l'intolérance au glucose, et l'altération de la glycémie à jeun, en induisant une sécrétion d'insuline glucodépendante sans réduction de la motilité intestinale.

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