C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/12 (2006.01) A61K 31/422 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2449160
Compounds are provided which have the structure: (formula I); wherein Q is C or N; R2a, R2b, R2c, X1 to X7, R1, R2, R3, R3a, R4, A, Y, m, and n are as defined herein, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents. The present invention further provides a method for treating obesity and dyslipidemia in mammals including humans through simultaneous inhibition of peroxisome proliferator activated receptor-.gamma. (PPAR.gamma.) and stimulation of peroxisome proliferator activated receptor- .alpha. (PPAR.alpha.).
L'invention porte sur des composés ayant la structure: (formule I) dans laquelle Q représente C ou N; R?2a¿, R?2b¿, R?2c¿, X¿1? à X¿7?, R?1¿, R?2¿, R?3¿, R?3a¿, R?4¿, A, Y, m et n sont tels que définis dans la demande. Ces composés sont utiles comme agents antidiabétiques, hypolipidémiques et comme agents contre l'obésité. Cette invention porte également sur un procédé de traitement de l'obésité et de la dyslipidémie chez les mammifères, y compris chez l'homme, par inhibition simultanée du récepteur-.gamma. activé par le proliférateur peroxisome (PPAR-.gamma.) et par la stimulation de ce récepteur
Cheng Peter T.
Hariharan Narayanan
Zhang Hao
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
LandOfFree
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