Bicyclic pyrrole derivatives as mcp-1 inhibitors

Details Bicyclic pyrrole derivatives as mcp-1 inhibitors Bicyclic pyrrole derivatives as mcp-1 inhibitors

A - Human Necessities

61

K

A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/425 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2319082

A pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt or esters of amides thereof, which is an inhibitor of monocyte chemoattractant protein-1 and wherein A and B together form an optionally substituted 5-membered aromatic ring which includes at least one heteroatom; X is CH2 or SO2; R1 is an optionally substituted aryl or heteroaryl ring; R2 is selected from a range of organic groups including carboxy, and R3 is hydrogen, or a range of organic groups; in combination with a pharmaceutically acceptable carrier. Certain compounds of formula (I) are novel and these form a further aspect of the invention.

L'invention porte sur une préparation pharmaceutique comportant un composé de formule (I) ou l'un de ses sels ou esters d'amide pharmacocompatible agissant comme inhibiteur de la protéine dite MCP-1 (protéine chimiotactique vis à vis des monocytes N·1). Dans la formule: A et B forment ensemble un cycle aromatique facultativement substitué à 5 éléments comportant au moins un hétéroatome; X est CH¿2? ou SO¿2?; R?1¿ est un cycle aryle ou hétéroaryle facultativement substitué; R?2¿ est choisi parmi une série de groupes organiques dont carboxy, R?3¿ est H, ou une série de groupes organiques. L'ensemble est associé à un excipient pharmacocompatible. Certains composés de formule (I) sont nouveaux et ces formes font partie de l'invention.

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