Biodegradable copolymers linked to segment with a plurality...

C - Chemistry – Metallurgy – 08 – G

Patent

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Details

C08G 63/00 (2006.01) A61K 47/34 (2006.01) A61K 47/48 (2006.01) A61L 31/10 (2006.01) A61L 31/16 (2006.01) C08G 63/02 (2006.01) C08G 63/06 (2006.01) C08G 63/08 (2006.01) C08G 73/10 (2006.01)

Patent

CA 2440394

Biocompatible biodegradable copolymer comprising a polymeric or copolymeric segment which is capped at one end and linked at the other end to a polymeric or copolymeric segment having a plurality of functional groups pendant thereto. Some or all of the functional groups are reacted to attach a moiety containing an aminoxyl- containing radical, a moiety comprising another drug molecule residue or a moiety comprising a biologically active agent residue. The invention can be used for a number of biomedical applications including a drug release system for an implant.

L'invention concerne un polymère ou copolymère biocompatible et biodégradable bloqué à une extrémité et présentant un hydroxyle à radical libre à l'autre extrémité. L'hydroxyle à radical libre peut être mis en réaction pour lier plusieurs groupes fonctionnels dont quelques-uns ou chacun peut être mis en réaction pour se fixer directement, ou par l'intermédiaire d'une molécule d'espacement, à un fragment présentant un radical aminoxyle, ou à un fragment contenant le résidu d'une autre molécule de médicament, ou à un fragment contenant le résidu d'un autre agent bioactif.

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