Delivery system to modulate immune response

Details Delivery system to modulate immune response Delivery system to modulate immune response

A - Human Necessities

61

K

A61K 9/50 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2322472

A microsphere containing an immunogen bound to an innert particle having a mesh size of greater than about 35 mesh for site-specific release and induction of an immune response. The immune response may be an overall enhanced T lymphocyte immune response or a selective response. The physical and chemical characteristics and/or modes of administration of the microsphere may be engineered to increase TH1 lymphocytes for treatment of cancer of infectious disease. The microencapsulated immunogen has an enteric coating for oral administration.

L'invention porte sur des microsphères contenant un immunogène lié à une particule inerte d'un maillage supérieur à environ 35, se libérant en un site spécifique et induisant une réponse immunitaire. Ladite réponse immunitaire peut être soit de renforcement général des lymphocytes T, soit sélective. Les caractéristiques physiques et chimiques et/ou les modes d'administration des microsphères peuvent être travaillés pour accroître les lymphocytes T¿H?1 en vue du traitement du cancer ou des maladies infectieuses. L'immunogène microencapsulé est doté d'un enrobage entérique favorisant son administration par voie orale.

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