Mitotic kinesin inhibitors

Details Mitotic kinesin inhibitors Mitotic kinesin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4375 (2006.01) C07D 403/12 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2485343

The present invention relates to azaquinazolinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

L'invention concerne des composés azaquinazolinone utiles dans le traitement de maladies de prolifération cellulaire, dans le traitement de troubles associés à l'activité de kinésine KSP, et dans l'inhibition de la kinésine KSP. L'invention concerne aussi des compositions comprenant ces composés, ainsi que des méthode d'utilisation de ces compositions afin de traiter la cancer chez des mammifères.

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