C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/18 (2006.01) A61K 31/47 (2006.01) A61K 31/573 (2006.01) A61K 31/58 (2006.01) A61P 11/06 (2006.01)
Patent
CA 2701723
The present application relates to crystalline 1,2-ethanedisulfonic acid salt and N,N'-dibenzylethylenediamine salt of montelukast. The salts are useful as therapeutic agents for the treatment of leukotriene mediated diseases and disorders. This application also relates to processes and intermediates for preparing the said salts and pharmaceutical compositions comprising the salts and optionally other therapeutic agents.
La présente invention porte sur un sel d'acide 1,2-éthanedisulfonique cristallin et sur un sel de N,N'-dibenzyléthylènediamine de montélukast. Les sels sont utiles comme agents thérapeutiques pour le traitement de maladies et troubles à médiation par les leucotriènes. Cette demande porte également sur des procédés et des intermédiaires pour préparer lesdits sels et sur des compositions pharmaceutiques comprenant les sels et facultativement d'autres agents thérapeutiques.
Merck Frosst Canada Ltd.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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