Triazolopyridine jak inhibitor compounds and methods

Details Triazolopyridine jak inhibitor compounds and methods Triazolopyridine jak inhibitor compounds and methods

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/444 (2006.01) A61K 31/4545 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61P 9/00 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2726844

A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined herein, are useful as JAK kinase inhibitors. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of JAK kinase activity in a patient are disclosed.

Composé de formule (I), y compris ses énantiomères, diastériomères, tautomères ou sels pharmaceutiquement acceptables correspondants, sachant que R1, R2, R3, R4 et R5 sont tels que définis selon l'invention, ce composé étant utile comme inhibiteur de JAK kinase. On décrit une composition pharmaceutique comprenant un tel composé et un vecteur, adjuvant ou véhicule pharmaceutiquement acceptable, et des procédés de traitement ou d'atténuation de la sévérité d'une maladie ou d'une affection en réaction à l'inhibition de l'activité JAK kinase chez un patient.

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