Combinations and modes of administration of therapeutic...

Details Combinations and modes of administration of therapeutic... Combinations and modes of administration of therapeutic...

A - Human Necessities

61

K

A61K 31/337 (2006.01) A61K 31/282 (2006.01) A61K 31/395 (2006.01) A61K 31/436 (2006.01) A61K 31/513 (2006.01) A61K 31/517 (2006.01) A61K 31/7068 (2006.01) A61K 33/24 (2006.01) A61K 47/42 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2598239

The present invention provides combination therapy methods of treating proliferative diseases (such as cancer) comprising a first therapy comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a second therapy which may include, for example, radiation, surgery, administration of chemotherapeutic agents, or combinations thereof. Also provided are methods of administering to an individual a drug taxane in a nanoparticle composition based on a metronomic dosing regime.

La présente invention concerne des méthodes de traitement combiné destinées à traiter des maladies prolifératives (telles que le cancer) et comprenant un premier traitement consistant à administrer à un individu une dose efficace d'un taxane dans une composition nanoparticulaire et un second traitement pouvant comprendre, par exemple, une irradiation, une chirurgie, une administration d'agents chimiothérapeutiques ou une combinaison de celles-ci. L'invention concerne également des méthodes destinées à administrer à un individu un taxane médicamenteux dans une composition nanoparticulaire sur la base d'un régime de dosage métronomique.

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