A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/48 (2006.01) A61K 31/7105 (2006.01) A61K 38/18 (2006.01) A61K 38/55 (2006.01) A61P 17/00 (2006.01) A61P 17/06 (2006.01) C12N 9/64 (2006.01) C12N 15/85 (2006.01) C12Q 1/25 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2626361
The invention relates to the treatment or prevention of an inflammatory skin disease, disorder or condition, by modulating a protein that is normally regulated by caspase-8 in the skin or by increasing caspase-8 activity or level in the skin. Another aspect of the invention relates to methods for diagnosing an inflammatory skin disease, disorder or condition or a predisposition to develop said disease disorder or condition in an individual. Further aspects of the invention relate to methods for identifying target proteins involved in the course or pathology of an inflammatory skin disease, disorder or condition and to methods of screening a candidate compound for treating said disease, disorder or condition. In particular, the invention relates to inflammatory skin diseases such as atopic dermatitis and psoriasis.
L'invention permet de traiter ou prévenir une maladie, affection ou état cutané inflammatoire, en modulant une protéine qui est normalement régulée par la caspase-8 dans la peau ou en augmentant l'activité ou le niveau de la caspase-8 dans la peau. Dans un autre aspect, l'invention concerne des procédés permettant de diagnostiquer une maladie, une affection ou un état cutané inflammatoire ou la prédisposition d'un individu à développer une telle maladie, affection, ou un tel état. D'autres aspects de l'invention se rapportent à des procédés permettant d'identifier des protéines cibles impliquées dans l'évolution ou la pathologie d'une maladie, affection ou état cutané et à des procédés de criblage d'un composé candidat destiné au traitement de ladite maladie, affection ou état. En particulier, l'invention concerne des maladies cutanées inflammatoires telles que la dermatite atopique et le psoriasis.
Kang Tae-Bong
Kim Jin Chul
Kovalenko Andrei
Wallach David
Borden Ladner Gervais Llp
Ltd. Yeda Research And Development Co.
LandOfFree
Pharmaceutical compositions and diagnostic methods for... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pharmaceutical compositions and diagnostic methods for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical compositions and diagnostic methods for... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1911735