C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 309/06 (2006.01) A61K 31/045 (2006.01) A61K 31/593 (2006.01) C07C 401/00 (2006.01) C07D 303/14 (2006.01) C07D 307/33 (2006.01) C07D 309/04 (2006.01)
Patent
CA 2289209
Novel cyclic ether vitamin D3 compounds having a cyclic ether side chain are disclosed. These compounds were first identified as metabolites of 3-epi vitamin D3 produced via a tissue-specific metabolic pathway which catalyzes the formation of a cyclic ether structure. Also disclosed are 1.alpha.(OH) 3-epi vitamin D3 compounds, which are produced via the epimerization of a 3-.beta.-hydroxyl group of 1 .alpha.(OH) vitamin D3 precursor in vivo. The vitamin D3 compounds of the present invention can be used as substitutes for natural and synthetic vitamin D3 compounds.
Nouveaux composés de vitamine D3 comportant une chaîne latérale d'éther cyclique. Lesdits composés ont d'abord été identifiés en tant que métabolites de formes 3-épi de vitamine D3 produits via une voie métabolique spécifique à des tissus qui catalyse la formation d'une structure d'éther cyclique. La présente invention concerne également des composés de 1 alpha (OH)3-épi-vitamine D3 qui sont produits via l'épimérisation d'un groupe 3- beta -hydroxyle d'un précurseur sous forme de 1 alpha (OH)vitamine D3 in vivo. Lesdits composés de vitamine D3 peuvent être utilisés comme substituts de composés de vitamine D3 naturelle et synthétique.
Borden Ladner Gervais Llp
Women & Infants Hospital
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