Method for treating vascular obstructions caused by abnormal...

Details Method for treating vascular obstructions caused by abnormal... Method for treating vascular obstructions caused by abnormal...

A - Human Necessities

61

K

A61K 31/765 (2006.01) A61K 31/77 (2006.01)

Patent

CA 2115361

METHOD FOR TREATING VASCULAR OBSTRUCTIONS CAUSED BY ABNORMAL CELLS ABSTRACT In accordance with the present invention, a method is provided for treating ischemia resulting from microvascular compromise caused by abnormal cells in the blood stream, which is often a complication of malaria and leukemia. The method is especially useful for treating cerebral malaria. The method comprises administering to an animal or human with the microvascular compromise a therapeutically effective amount of a surface active copolymer with the following general formula: HO(C2H4O)b(C3H6O)a(C2H4O)bH wherein a is an integer such that the hydrophobe represented by (C3H6O) has a molecular weight of approximately 950 to 4000 daltons, preferably about 1200 to 3500 daltons, and b is an integer such that the hydrophile portion represented by (C2H4O) constitutes approximately 50% to 90% by weight of the copolymer.

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