Gastroretentive controlled release microspheres for improved...

Details Gastroretentive controlled release microspheres for improved... Gastroretentive controlled release microspheres for improved...

A - Human Necessities

61

K

A61K 9/52 (2006.01) A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 31/34 (2006.01) A61K 31/415 (2006.01) A61K 31/425 (2006.01) A61K 31/43 (2006.01) A61K 31/44 (2006.01) A61K 31/65 (2006.01)

Patent

CA 2285580

There is provided a drug delivery composition for the controlled release of an active agent in the stomach environment over a prolonged period of time which comprises a microsphere comprising an active ingredient in the inner core of the microsphere and (i) a rate controlling layer of a water insoluble polymer and (ii) an outer layer of a bioadhesive agent in the form of a cationic polymer.

L'invention concerne une composition d'administration de médicaments assurant une libération régulée d'un agent actif dans le milieu gastrique pendant une période prolongée, la composition comprenant une microsphère contenant un ingrédient actif dans son noyau intérieur, ainsi que (i) une couche de régulation de vitesse d'un polymère insoluble dans l'eau et (ii) une couche extérieure d'un agent bioadhésif sous forme de polymère cationique.

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