A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/52 (2006.01) A61K 31/675 (2006.01) G01N 33/564 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2205184
A method for treating autoimmune disease, or the pain and/or insomnia associated with autoimmune disease, in a mammalian subject, particularly a human, which method comprises administering a therapeutically effective amount of certain 2-amino purine compounds to the subject. The compounds particularly useful are antiviral compounds exemplified by acyclovir, valacyclovir, penciclovir and famciclovir. The compounds are administered at doses significantly higher (4 to 12 times) than the dose level currently approved and used to treat currently recognized manifestations of viral infections. Currently approved doses result in blood levels of about 0.5-1.0 micrograms/ml. This new technique results in blood levels of about 3-10 micrograms/ml with about 6 micrograms per ml being optimal.
Procédé de traitement d'une maladie auto-immune ou de la douleur et/ou de l'insomnie associées à cette maladie chez un mammifère, en particulier l'homme, qui consiste à administrer au sujet une quantité thérapeutiquement efficace de certains composés de 2-amino purine. Les composés particulièrement efficaces sont des composés antiviraux, tels qu'acyclovir, valacyclovir, pencyclovir et famciclovir. Ces composés sont administrés à des doses sensiblement supérieures (4 à 12 fois) au niveau de dosage actuellement admis et utilisé pour traiter habituellement les manifestations reconnues d'infections virales. Avec les doses actuellement admises, on obtient des niveaux sanguins de 0,5-1 microgramme/ml. Cette nouvelle technique permet d'obtenir des niveaux sanguins de 3-10 microgrammes/ml, le niveau optimum étant de 6 microgrammes/ml.
Exley Ray W.
Fetherstonhaugh & Co.
LandOfFree
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