Method and apparatus for emission computed tomography using...

Details Method and apparatus for emission computed tomography using... Method and apparatus for emission computed tomography using...

G - Physics

06

K

G06K 9/00 (2006.01) G01N 21/47 (2006.01) G21K 5/10 (2006.01)

Patent

CA 2485673

An optical tomographic system wherein the localization of secondary emitters (3,4) within an object of interest (2) is determined using the temporal signatures (12A, 12B, 12C) of secondary emission arising from the object being illuminated by an external primary source beam (1) that is non-parallel, such as a cone beam (1), while the object is moving relative to said beam (1) in a controlled manner. A unique set of secondary emitter spots is localized within the object and, when combined with a computed 3D reconstruction (35) of the object from its primary cone beam projections, creates an image of the secondary emitters (3,4) in the object so as to enable quantitative three- dimensional imaging of fluorescent labeled molecular probes (3,4) in a biological cell, for example.

L'invention porte sur un système tomographique temporel dans lequel la localisation d'émetteurs secondaires (3, 4) dans un objet d'intérêt (2) est déterminée au moyen des signatures temporelles (12A, 12B, 12C) de l'émission secondaire issue de l'objet éclairé par un faisceau source primaire externe (1) qui n'est pas parallèle, tel qu'un faisceau conique (1), pendant que l'objet se déplace par rapport audit faisceau (1) de manière contrôlée. Un ensemble unique d'emplacements d'émetteurs secondaires est localisé dans l'objet et, lorsqu'il est combiné à une reconstruction informatique 3D (35) de l'objet à partir de ses projections de faisceau conique primaire, crée une image des émetteurs secondaires (3,4) dans l'objet afin de permettre l'imagerie tridimensionnelle quantitative des sondes moléculaires marquées (3,4) dans une cellule biologique par exemple.

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