Synthetic endogenous cannabinoids analogues and uses thereof

Details Synthetic endogenous cannabinoids analogues and uses thereof Synthetic endogenous cannabinoids analogues and uses thereof

C - Chemistry, Metallurgy

07

C

C07C 43/178 (2006.01) A61K 31/08 (2006.01) C07B 59/00 (2006.01) C07C 43/15 (2006.01)

Patent

CA 2326766

The present invention relates to a compound of the general formula (I) which is a non-hydrolysable analogue of endogenous cannabinoids, which are found to be more potent therapeutic agents as they are more stable, for example, to hydrolytic cleavage in the gastrointestinal tract. The cannabinoid analogues of the invention have a therapeutic value. Therefore, pharmaceutical compositions comprising as active ingredient a therapeutically effective amount of at least one compound of the invention may be prepared. Such compositions may be used as anti-inflammatory, anti-asthmatic, analgetic, hypotensive, antiemetic or anti-spasmodic compositions, and as compositions for treating and/or preventing glaucoma or migraine, or as compositions for relieving symptoms of multiple sclerosis and mood stimulating compositions.

La présente invention concerne des composés de formule générale (1) analogues, non hydrolysables, de cannabinoïdes endogènes, qui sont des agents thérapeutiques plus puissants en raison de leur plus grande stabilité, par exemple, par rapport à la scission hydrolytique dans le tractus gastro-intestinal. Les analogues de cannabinoïdes de l'invention possèdent une valeur thérapeutique, ce qui permet la préparation de compositions pharmaceutiques comprenant, en tant que principe actif, une quantité efficace, sur le plan thérapeutique, d'au moins un des composés de l'invention. De telles compositions peuvent être utilisées comme anti-inflammatoire, antiasthmatique, analgésique, hypotenseur, antiémétique ou antispasmodique, ou pour le traitement et/ou pour la prévention de glaucome ou de migraine, ou pour le traitement des symptômes de sclérose multiple et de stimulation de l'humeur.

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