Diagnostic reagents for the detection of antibodies to ebv

Details Diagnostic reagents for the detection of antibodies to ebv Diagnostic reagents for the detection of antibodies to ebv

G - Physics

01

N

G01N 33/569 (2006.01) C07K 14/05 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2131874

The present invention is directed to diagnostic reagents for the detection of antibodies against the Epstein Barr Virus and a method for the detection of antibodies to the Epstein Barr Virus in a sample. The diagnostic reagents according to the invention comprise a combination of at least part of an Epstein Barr viral structural protein, preferably a Epstein Barr VCA-protein or an Epstein Barr MA protein, and at least part of an Epstein Barr EBNA protein. Preferably, the VCA-protein is VCA-p18 protein, the MA-protein is MA-gp350/220 protein and the EBNA-protein is EBNA-1 protein. It has been found that the combination of a VCA-protein or a MA-protein, and an EBNA protein, into a single diagnostic assay yields an EBV-antibody detection method with greater sensitivity and accuracy than current methods.

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