A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 15/28 (2006.01) A61K 31/4025 (2006.01) A61K 31/661 (2006.01) A61K 31/7028 (2006.01) A61K 39/395 (2006.01) A61L 15/44 (2006.01) A61P 17/02 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2509392
The present invention relates to the ability of SAP to suppress the differentiation of monocytes into fibrocytes. It also relates to the ability of IL-4 and IL-3 to enhance the differentiation of monocytes into fibrocytes. Methods and compositions for binding SAP, decreasing SAP levels and suppressing SAP activity are provided. Methods of using, inter alia, CPHPC, the 4,6-pyruvate acetyl of beta-D-galactopyranose, ethanolamines, high EEO agarose, IL-4, and IL-13, and anti-SAP antibodies and fragments thereof to increase monocyte differentiation into fibrocytes are provided. These methods are useful in a variety of applications, including wound healing. Wound dressings are also provided. Finally, the invention includes assays for detecting the ability of various agents to modulate monocyte differentiation into fibrocytes and to detect monocyte defects.
La présente invention concerne la capacité de SAP de supprimer la différenciation de monocytes dans des fibroblastes. Cette invention concerne aussi la capacité de IL-4 et de IL-3 de renforcer la différenciation de monocytes dans des fibroblastes. Cette invention concerne aussi des techniques et des compositions de liaison de SAP, de baisse des niveaux de SAP et de suppression de l'activité SAP. Cette invention concerne aussi des techniques d'utilisation, entre autres choses, de CPHPC, le 4,6-pyruvate acétyle de bêta-D-galactopyranose, des éthanolamines, d'agarose EEO de haute teneur, d'IL-4 et d'IL-3 et, d'anticorps anti-SAP et de fragments de ceux-ci destinés à augmenter la différenciation de monocytes dans des fibroblastes. Ces techniques conviennent pour une variété d'applications, notamment pour guérir des lésions. Cette invention concerne aussi des pansements. Cette invention concerne enfin des dosages de détection de la capacité de divers agents de moduler la différenciation de monocytes dans des fibroblastes et de détection d'anomalies de monocyte.
Gomer Richard
Pilling Darrell
Kirby Eades Gale Baker
William Marsh Rice University
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