Prostaglandin e2/f2.alpha. combination for treating...

Details Prostaglandin e2/f2.alpha. combination for treating... Prostaglandin e2/f2.alpha. combination for treating...

A - Human Necessities

61

K

A61K 31/557 (2006.01) A61M 31/00 (2006.01)

Patent

CA 2314369

A method of treating and a composition for treating erectile dysfunction in a male patient or female sexual arousal dysfunction, comprising the step of administering to the patient a unit dose of a formulation comprising an effective amount of a prostaglandin, namely prostaglandin E1, prostaglandin E2, or pharmaceutically acceptable salts or derivatives thereof, wherein the prostaglandin is formulated with a small amount of prostaglandin F.alpha.2 together with a pharmaceutically acceptable delivery medium and/or a lubricant. The method also contemplates PGE2 with phentolamine mesylate, with or without PGF2.alpha..

L'invention concerne un procédé et une composition de traitement du dysfonctionnement érectile chez l'homme ou du dysfonctionnement de l'excitation sexuelle chez la femme, ce procédé comprenant les étapes consistant à administrer au patient une dose unitaire d'une formulation comprenant une dose efficace d'une prostaglandine, à savoir la prostaglandine E¿1?, la prostaglandine E¿2?, ou des sels ou dérivés de celles-ci, acceptables sur le plan pharmacologique, la prostaglandine étant formulée à l'aide d'une petite dose de prostaglandine F¿.alpha.2? et d'un milieu d'apport, acceptable sur le plan pharmacologique, et/ou d'un lubrifiant. Ce procédé concerne également la prostaglandine PGE¿2? formulée avec du mésylate de phentolamine, avec ou sans PGF¿2.alpha.?.

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