A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 31/18 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) A61K 38/51 (2006.01) A61K 38/52 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2462443
The present invention provides a method for treating structural heart disease in a subject, comprising administering an effective amount of an inhibitor of CaMKII to the subject, whereby the administration of the inhibitor treats the structural heart disease in the subject. Also provided are transgenic animal models for treating structural heart disease. Further provided is a means of screening for a compound that can treat structural heart disease.
La présente invention concerne une méthode permettant de traiter une maladie cardiaque structurelle chez un sujet. Ladite méthode consiste notamment à administrer au sujet une dose efficace d'un inhibiteur de la CaMKII, ce qui a pour effet de traiter la maladie cardiaque structurelle. L'invention a également trait à des modèles animaux transgéniques servant au traitement d'une maladie cardiaque structurelle, ainsi qu'à un moyen de criblage d'un composé apte à traiter une maladie cardiaque structurelle.
Gowling Lafleur Henderson Llp
Vanderbilt University
LandOfFree
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