Sulfonic acid derivatives in the treatment of viral diseases

Details Sulfonic acid derivatives in the treatment of viral diseases Sulfonic acid derivatives in the treatment of viral diseases

C - Chemistry, Metallurgy

07

C

C07C 335/20 (2006.01) A61K 31/185 (2006.01) A61K 31/265 (2006.01) A61K 31/27 (2006.01) C07C 309/42 (2006.01) C07C 309/51 (2006.01) C07C 327/42 (2006.01) C07C 329/04 (2006.01) C07C 329/10 (2006.01) C07C 329/20 (2006.01) C07C 333/08 (2006.01) C07C 333/24 (2006.01)

Patent

CA 2130360

Sulfonic acid stilbenes of formula (I) wherein B is -CH=CH- (cis or trans), -CH2CH2- or a bond; X is NH or oxygen; Y is oxygen or sulfur; Z is NH, CH2, oxygen or sulfur; R1 is hydrogen, C1-C4 alkyl, -CH2-Ar, or -Ar wherein Ar is a phenyl or naphthyl group, the phenyl or naphthyl groups optionally substituted by a C1-C4 alkyl or SO3M3 group; and M1, M2, and M3 are each independently a hydrogen or a pharmaceutically acceptable cation sulfonic acid stilbenes block the infection of cells by HSV, HIV and CMV and these compounds can be used to prevent viral infection.

Stilbènes d'acide sulfonique de formule (I), où B est -CH=CH- (cis ou trans), -CH2CH2- ou une liaison; X est NH ou de l'oxygène; Y est de l'oxygène ou du soufre; Z est NH, CH2, de l'oxygène ou du soufre; R1 est de l'hydrogène, un alkyle C1-C4, -CH2-Ar ou -Ar, où Ar est un phényle ou un naphtyle, le phényle ou le naphtyle étant facultativement avec substitution par un alkyle C1-C4 ou un groupe SO3M3; M1, M2 et M3 sont chacun indépendamment un hydrogène ou un cation acceptable en pharmacie; ces stilbènes bloquent l'infection des cellules par HSV, VIH et CMV et peuvent prévenir l'infection virale.

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