Heteroaryl diazabicycloalkanes, their preparation and use

Details Heteroaryl diazabicycloalkanes, their preparation and use Heteroaryl diazabicycloalkanes, their preparation and use

C - Chemistry, Metallurgy

07

D

C07D 487/08 (2006.01) A61K 31/395 (2006.01) A61K 31/439 (2006.01) A61K 31/551 (2006.01) A61K 49/00 (2006.01) A61P 25/28 (2006.01) A61P 25/30 (2006.01) A61P 29/00 (2006.01) C07D 471/08 (2006.01)

Patent

CA 2365258

The present invention relates to novel heteroaryl diazabicycloalkane derivatives represented by general formula (I), any of its enantiomers or any mixture thereof, an N oxide thereof, a pharmaceutically acceptable salt thereof, in a labelled or un-labelled form, which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neurodegeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

La présente invention concerne de nouveaux dérivés de diazabicycloalcane hétéroaryle représentés par la formule générale (I), (formule I) n'importe quels énantiomères ou mélanges de celui-ci, son N-oxyde, son sel pharmaceutiquement acceptable, sous forme étiquetée ou non étiquetée, qui se sont avérés être des ligands cholinergiques sur les récepteurs nicotiniques de l'acétylcholine. Grâce à leur profil pharmacologique, les composés de l'invention pourraient servir au traitement de maladies et de troubles aussi variés que ceux liés au système cholinergique du système nerveux central (SNC), ceux liés à la contraction des muscles lisses, des maladies et de troubles endocriniens, des maladies et de troubles liés à la neurodégénération, des maladies et de troubles liés à l'inflammation, à la douleur et au symptôme de sevrage provoqué par la cessation d'abus d'intoxicants.

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