A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/38 (2006.01) A61K 9/22 (2006.01) A61K 9/28 (2006.01) A61K 31/4439 (2006.01) A61K 47/04 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61K 47/32 (2006.01) A61K 47/44 (2006.01) A61P 1/04 (2006.01)
Patent
CA 2466726
It is intended to disclose preparation composition which enable convenient production of sustained-release preparation composition containing acid-unstable physiologically active compound and have the desired sustained-release properties. Namely, preparation composition comprising a core containing an acid-unstable physiologically active compound and a coating with which the core is coated and which contains a mixture of a water-insoluble polymer and an enteric polymer. The preparation composition according to the present invention makes it possible to maintain an effective concentration in blood of the physiologically active compound over a long time, thereby improving its therapeutic effect. Moreover, the composition according to the present invention remains stable over prolonged storage.
L'invention concerne des compositions de préparation permettant une production commode de compositions de préparation à libération prolongée contenant des composés actifs au plan physiologique, instables aux acides, et possédant les propriétés de libération prolongées recherchées. L'invention porte notamment sur des compositions de préparation comprenant un noyau contenant un composé actif au plan physiologique et instable aux acides, et une pellicule enrobant le noyau et contenant un mélange de polymère insoluble dans l'eau et de polymère gastro-résistant. Lesdites compositions de préparation permettent le maintien d'une concentration efficace dans le sang du composé actif au plan physiologique, sur une longue période, ce qui permet d'améliorer son action thérapeutique. Par ailleurs, lesdites compositions restent stables en stockage prolongé.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Eisai Co. Ltd.
Eisai R&d Management Co. Ltd.
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