C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 39/02 (2006.01) A61K 39/09 (2006.01) A61K 39/385 (2006.01) A61P 31/04 (2006.01) C07K 14/315 (2006.01) C07K 19/00 (2006.01) C12N 15/31 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2319404
The present invention relates to recombinant lipidated PsaA proteins and recombinant constructs from which such lipidated PsaA proteins may be expressed. The invention relates further to lipidated PsaA proteins in which lipidation is effected by the use of a heterologous leader sequence derived from the ospA gene of Borrelia burgdorferi, which leader sequence is joined in translational reading frame with the psaA structural gene. The invention also provides methods of preparation of lipidated PsaA proteins and use of such proteins in immunological compositions. Also provided are vaccines comprising immunogenic lipidated PsaA proteins and methods of use of such vaccines in the prevention and treatment of S.pneumoniae infection.
La présente invention concerne des protéines PsaA recombinées lipidées ainsi que des constructions recombinées à partir desquelles on peut exprimer ces protéines PsaA lipidées. L'invention concerne également des protéines PsaA lipidées dans lesquelles la lipidation est effectuée par l'utilisation d'une séquence hétérologue initiale dérivée du gène ospA de Borrelia burgdorferi, laquelle séquence initiale est jointe dans un cadre de lecture de traduction au gène structurel psaA. L'invention concerne également des méthodes de préparation de protéines PsaA lipidées et d'utilisation de ces protéines dans des compositions immunologiques. L'invention concerne aussi des vaccins comprenant des protéines PsaA immunogènes lipidées et des méthodes d'utilisation de ces vaccins dans la prévention et le traitement d'infections S.pneumoniae.
Ades Edwin W.
Carlone George M.
De Barun K.
Huebner Robert C.
Sampson Jacquelyn S.
Aventis Pasteur
Center For Disease Control And Prevention
Mbm Intellectual Property Law Llp
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