Vector encoding suicide and marker constructs

Details Vector encoding suicide and marker constructs Vector encoding suicide and marker constructs

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A01K 67/00 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2411208

The present invention provides a vector encoding a detectable cell surface marker and a suicide construct, and cells and a non-human mammal transduced with this vector. Introduction of lymphocytes transduced with this vector, after allogeneic bone marrow transplantation, serves to treat or prevent complications from the bone marrow transplant, including graft versus host disease.

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