Antiviral acyclic nucleoside derivatives

Details Antiviral acyclic nucleoside derivatives Antiviral acyclic nucleoside derivatives

C - Chemistry, Metallurgy

07

D

167/218, 260/255

C07D 239/47 (2006.01) A61K 31/505 (2006.01) C07D 239/46 (2006.01) C07D 473/00 (2006.01)

Patent

CA 2005815

The present invention relates to valinate esters of purine nucleosides containing an acyclic side chain, and their use in medical therapy, particularly the treatment and prophylaxis of herpes virus infections. Also provided are pharmaceutical formulations and processes for the preparation of valinate esters according to the invention. The valinate esters are of formula (I): Image wherein R and R1 are independently selected from a hydrogen atom or a valine residue providing at least one of R and R1 represents a valine residue.

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