Hedgehog pathway inhibitors

Details Hedgehog pathway inhibitors Hedgehog pathway inhibitors

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61K 31/00 (2006.01) A61K 47/22 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2750639

This disclosure generally relates to methods useful for improving, for example, blood vessel density and/or blood vessel patency to a tissue by administration of a hedgehog pathway inhibitor. In certain embodiments, the hedgehog pathway inhibitor is administered with an agent to improve the delivery of the agent to the tissue. In certain embodiments, the tissue comprises tumor tissue.

La présente invention concerne, de façon générale, des procédés permettant d'améliorer, par exemple, la densité des vaisseaux sanguins et/ou la perméabilité des vaisseaux sanguins irriguant un tissu grâce à l'administration d'un inhibiteur de la voie Hedgehog. Dans certains modes de réalisation, l'inhibiteur de la voie Hedgehog est administré en même temps qu'un agent en vue d'améliorer la délivrance dudit agent en direction du tissu. Dans certains modes de réalisation, ledit tissu comprend du tissu tumoral.

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