Methods of treatment using wisp polypeptides

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2425145

The present invention relates to methods for the treatment and repair of cartilage, including cartilage damaged by injury or degenerative cartilagenous disorders, including arthritis, comprising the administration of WISP polypeptide. Optionally, the administration may be in combination with one or more cartilage agents (e.g., peptide growth factor, catabolism antagonist, osteo-, synovial, anti-inflammatory factor). Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or degenerative cartilagenous disorders comprising the administration of WISP polypeptide in combination with standard surgical techniques. Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or degenerative cartilagenous disorders comprising the administration of chondrocytes previously treated with an effective amount of WISP polypeptide.

La présente invention concerne des techniques de traitement et de réparation de cartilage, notamment les cartilage abîmés par lésion ou les cartilaginopathies dégénératives, y compris l'arthrite. Ces techniques consistent à administrer des polypeptides WISP. Cette administration peut être, éventuellement, associée à celle d'un ou de plusieurs agents de cartilage (par exemple un facteur de croissance peptidique, un antagoniste du catabolisme, un facteur osseux, synovial, anti-inflammatoire). Dans une autre formule, cette invention concerne des techniques de traitement et de réparation de cartilage abîmé par lésion ou de cartilaginopathies dégénératives qui consistent en une administration de polypeptides WISP associée à des techniques chirurgicales standard. Dans une autre formule encore, cette invention concerne des techniques de traitement et de réparation de cartilage abîmé par lésion ou de cartilaginopathies dégénératives qui consistent en une administration de chondrocytes préalablement traités avec une quantité efficace de polypeptide WISP.

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