C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 17/02 (2006.01) A61K 38/16 (2006.01) A61K 39/00 (2006.01) A61K 39/35 (2006.01) A61K 47/48 (2006.01) C07K 16/18 (2006.01) C12P 21/00 (2006.01)
Patent
CA 2331012
The present invention relates to a method for the preparation of a conjugate comprising a first and a second polypeptide, said method comprising the steps of (a) incubating said first polypeptide in the presence of a heterobifunctional crosslinker comprising an N-hydroxylsuccinimide ester group and a maleimide group linked via a polyethylene oxide spacer; (b) removing excess heterobifunctional crosslinker; and (c) incubating the reaction product of step (b) with said second polypeptide, wherein said second polypeptide comprises at least one sulfhydryl group. Furthermore, the present invention relates to a conjugate obtainable by the method of the present invention. Also described is a pharmaceutical composition comprising the conjugate of the present invention and, optionally, a pharmaceutically acceptable carrier and/or diluent, and the use of the conjugate for the preparation of a pharmaceutical composition for preventing and/or treating an allergic disease or an autoimmune disease.
Borel Yves
Gelfand Erwin
Schelgel Werner
Aventis Behring Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
LandOfFree
Method for the production of conjugates and uses thereof for... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for the production of conjugates and uses thereof for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for the production of conjugates and uses thereof for... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1914853